AXKO-0046 (dihydrochloride)
AXKO-0046 dihydrochloride, indole derivative, is an uncompetitive Lactate dehydrogenase B (LDHB) selective inhibitor. AXKO-0046 dihydrochloride has LDHB inhibitory activity with an EC50 value of 42 nM. AXKO-0046 dihydrochloride can be used for the research of cancer metabolism[1].
Product Specifications
UNSPSC
12352005
Target
Lactate Dehydrogenase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/axko-0046-dihydrochloride.html
Concentration
10mM
Purity
99.71
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
[H]Cl.[H]Cl.C1(NCC(N2)=C(CCNCC3=CC=CC=C3)C4=C2C=CC=C4)CCCCCC1
Molecular Formula
C25H35Cl2N3
Molecular Weight
448.47
References & Citations
[1]Sachio Shibata, et al. Identification of the first highly selective inhibitor of human lactate dehydrogenase B. Sci Rep. 2021 Nov 1;11 (1) :21353.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
LDHB
Available Sizes
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