P-gp inhibitor 22

P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase[1].

Product Specifications

CAS Number

[1226674-74-3]

UNSPSC

12352005

Target

Apoptosis; P-glycoprotein

Type

Reference compound

Related Pathways

Apoptosis; Membrane Transporter/Ion Channel

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/p-gp-inhibitor-22.html

Solubility

10 mM in DMSO

Smiles

N#CC1=C(N)OC2=C(C3=CC(O)=CC=C3C=C2)C1C4=CC=CC=C4Cl

Molecular Formula

C20H13ClN2O2

Molecular Weight

348.78

References & Citations

[1]Ashraf H F Abd El-Wahab, et al. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Sci Rep. 2024 Mar 31;14 (1) :7589.