P-gp inhibitor 22
P-gp inhibitor 22 is a P-glycoprotein (P-gp) inhibitor that effectively inhibits P-pg and efflux function. P-gp inhibitor 22 induces apoptosis and accumulation of MCF-7/ADR cells processed in the S phase[1].
Product Specifications
CAS Number
[1226674-74-3]
UNSPSC
12352005
Target
Apoptosis; P-glycoprotein
Type
Reference compound
Related Pathways
Apoptosis; Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-22.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C(N)OC2=C(C3=CC(O)=CC=C3C=C2)C1C4=CC=CC=C4Cl
Molecular Formula
C20H13ClN2O2
Molecular Weight
348.78
References & Citations
[1]Ashraf H F Abd El-Wahab, et al. Design, synthesis and bioactivity study on oxygen-heterocyclic-based pyran analogues as effective P-glycoprotein-mediated multidrug resistance in MCF-7/ADR cell. Sci Rep. 2024 Mar 31;14 (1) :7589.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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