NF-56-EJ40
NF-56-EJ40 is a potent, high-affinity, and highly selective human SUCNR1 (GPR91) antagonist with an IC50 of 25 nM and a Ki of 33 nM, and shows almost no activity towards rat SUCNR1. NF-56-EJ40 has high affinity for humanized rat SUCNR1 with a Ki value of 17.4 nM[1].
Product Specifications
CAS Number
[2380230-73-7]
UNSPSC
12352005
Hazard Statement
H302, H312, H332
Target
Succinate Receptor 1
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/nf-56-ej40.html
Purity
99.92
Solubility
DMSO : 5 mg/mL (ultrasonic) |H2O : 4.55 mg/mL (ultrasonic; adjust pH to 9 with NaOH)
Smiles
O=C(NC1=C(CC(O)=O)C=CC=C1)C2=CC=CC(C3=CC=C(CN4CCN(C)CC4)C=C3)=C2
Molecular Formula
C27H29N3O3
Molecular Weight
443.54
Precautions
H302, H312, H332
References & Citations
[1]Haffke M, et al. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 2019 Oct;574 (7779) :581-585.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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