Compound 401
Compound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K in vitro.
Product Specifications
CAS Number
[168425-64-7]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Compound-401.html
Purity
99.97
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
O=C1C=C(N2CCOCC2)N=C3N1C=CC4=C3C=CC=C4
Molecular Formula
C16H15N3O2
Molecular Weight
281.31
Precautions
H302, H315, H319, H335
References & Citations
[1]Ballou LM, et al. Inhibition of mammalian target of rapamycin signaling by 2- (morpholin-1-yl) pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282 (33) :24463-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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