K1586
K1586 is an amidine derivative that efficiently targets Chk1. K1586 enhances the degradation of Chk1 that sensitizes colorectal cancer cells to ionizing radiation. K1586 shows anticancer effects[1].
Product Specifications
UNSPSC
12352005
Target
Checkpoint Kinase (Chk)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/k1586.html
Purity
99.63
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCN(CC)/C=N/C(C=C1)=CC2=C1N=C(S2)OC3=CC=C(Cl)C=C3
Molecular Formula
C18H18ClN3OS
Molecular Weight
359.87
References & Citations
[1]Hang Soo Kim, et al. Novel Amidine Derivative K1586 Sensitizes Colorectal Cancer Cells to Ionizing Radiation by Inducing Chk1 Instability. Int J Mol Sci. 2024 Apr 16;25 (8) :4396.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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