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JMS-17-2

JMS-17-2 is a potent and selective CX3CR1 antagonist with an IC50 of 0.32 nM. JMS-17-2 impairs metastatic seeding and colonization of breast cancer cells[1].

Product Specifications

CAS Number

1380392-05-1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

CX3CR1

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Endocrinology

Assay Protocol

https://www.medchemexpress.com/jms-17-2.html

Purity

99.59

Solubility

DMSO : 41.67 mg/mL (ultrasonic)

Smiles

O=C1C2=CC=CN2C3=C(C=CC=C3)N1CCCN4CCC(C5=CC=C(Cl)C=C5)CC4

Molecular Formula

C25H26ClN3O

Molecular Weight

419.95

Precautions

H302, H315, H319, H335

References & Citations

[1]Shen F, et al. Novel Small-Molecule CX3CR1 Antagonist Impairs Metastatic Seeding and Colonization of Breast Cancer Cells. Mol Cancer Res. 2016 Jun;14 (6) :518-27.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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