GNE-9605
GNE-9605 is a potent, orally active, selective Leucine-rich repeat kinase 2 (LRRK2) inhibitor with an IC50 value of 18.7 nM. GNE-9605 inhibits LRRK2 Ser1292 autophosphorylation. GNE-9605 can be used in research of Parkinson's disease (PD) [1].
Product Specifications
CAS Number
[1536200-31-3]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/GNE-9605.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
FC(C1=CN=C(NC2=C(Cl)N([C@@H]3[C@@H](F)CN(C4COC4)CC3)N=C2)N=C1NC)(F)F
Molecular Formula
C17H20ClF4N7O
Molecular Weight
449.83
Precautions
H302, H315, H319, H335
References & Citations
[1]Estrada AA, et, al. Discovery of highly potent, selective, and brain-penetrant aminopyrazole leucine-rich repeat kinase 2 (LRRK2) small molecule inhibitors. J Med Chem. 2014 Feb 13;57 (3) :921-36. |[2]Kumar S, et, al. Exploring the focal role of LRRK2 kinase in Parkinson's disease. Environ Sci Pollut Res Int. 2022 May;29 (22) :32368-32382.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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