Lys-CoA (TFA)
Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM) . Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM) . Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation[1][2].
Product Specifications
Product Name Alternative
Lys-coenzyme A
UNSPSC
12352005
Target
Histone Acetyltransferase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lys-coa-tfa.html
Purity
99.42
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32.O=C(O)C(F)(F)F
Molecular Formula
C33H54F3N10O21P3S
Molecular Weight
1108.82
References & Citations
[1]Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg Med Chem. 2003;11 (15) :3307-3313.|[2]Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell. 2000;5 (3) :589-595.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CBP/p300
Available Sizes
Frequently Asked Questions
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