Lys-CoA (TFA)

Lys-CoA TFA is a selective p300 histone acetyltransferase (HAT) inhibitor (IC50=50-500 nM) . Lys-CoA TFA displays >100-fold selectivity for p300 over PCAF (IC50=200 μM) . Lys-CoA TFA inhibits p300 HAT activity-dependent transcriptional activation[1][2].

Product Specifications

Product Name Alternative

Lys-coenzyme A

UNSPSC

12352005

Target

Histone Acetyltransferase

Type

Reference compound

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/lys-coa-tfa.html

Purity

99.42

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSCC(NCCCC[C@@H](C(N)=O)NC(C)=O)=O)=O)=O)(O)=O)(O)=O)O[C@H]1N2C=NC3=C(N)N=CN=C32.O=C(O)C(F)(F)F

Molecular Formula

C33H54F3N10O21P3S

Molecular Weight

1108.82

References & Citations

[1]Cebrat M, et al. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg Med Chem. 2003;11 (15) :3307-3313.|[2]Lau OD, et al. HATs off: selective synthetic inhibitors of the histone acetyltransferases p300 and PCAF. Mol Cell. 2000;5 (3) :589-595.