Apocynin-d3

Apocynin-d3 is the deuterium labeled Apocynin[1]. Apocynin is a selective NADPH-oxidase inhibitor with an IC50 of 10 μM[2][3][4].

Product Specifications

CAS Number

[80404-23-5]

Product Name Alternative

Acetovanillone-d3

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Apoptosis; Autophagy

Type

Isotope-Labeled Compounds

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.85

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])([2H])OC1=CC(C(C)=O)=CC=C1O

Molecular Formula

C9H7D3O3

Molecular Weight

169.19

Precautions

H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Stolk J, et al. Am J Respir Cell Mol Biol, 1994, 11 (1), 95-102.|[3]Stefanska J, et al. Mediators Inflamm, 2008, 106507.|[4]Impellizzeri D et al. Effect of apocynin, a NADPH oxidase inhibitor, on acute lung inflammation. Biochem Pharmacol. 2011 Mar 181 (5) :636-48.