FSL-1 (TFA)
FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2].
Product Specifications
UNSPSC
12352209
Target
Antibiotic; HSV; MMP; Toll-like Receptor (TLR)
Type
Peptides
Related Pathways
Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fsl-1-tfa.html
Purity
99.81
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[S-(2,3-Bispalmitoyloxypropyl)-CGDPKHPKSF(TFAsalt)]
Molecular Formula
C84H140N14O18S.xC2HF3O2
Molecular Weight
1666.16 (free acid)
References & Citations
[1]Cathryn J Kurkjian, et al. The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. Sci Rep. 2017 Dec 11;7 (1) :17355.|[2]William A Rose 2nd, et al. FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. Virol J. 2009 Nov 10;6:195.
Shipping Conditions
Dry Ice
Storage Conditions
-80°C
Scientific Category
Peptides
Clinical Information
No Development Reported
Isoform
HSV-2; MMP-9; TLR2; TLR6
Citation 01
Adv Sci (Weinh) . 2025 Sep 26:e02395.|Food Res Int. 2022 Dec;162 (Pt A) :112029.|J Ethnopharmacol. 2024 May 10:325:117824.|Int J Med Sci. 2022 Mar 21;19 (4) :631-639.
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