FSL-1 (TFA)

FSL-1 TFA, a bacterial-derived toll-like receptor 2/6 (TLR2/6) agonist, enhances resistance to experimental HSV-2 infection[1]. FSL-1 TFA induces MMP-9 production through TLR2 and NF-κB/AP-1 signaling pathways in monocytic THP-1 cells[2].

Product Specifications

UNSPSC

12352209

Target

Antibiotic; HSV; MMP; Toll-like Receptor (TLR)

Type

Peptides

Related Pathways

Anti-infection; Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/fsl-1-tfa.html

Purity

99.81

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[S-(2,3-Bispalmitoyloxypropyl)-CGDPKHPKSF(TFAsalt)]

Molecular Formula

C84H140N14O18S.xC2HF3O2

Molecular Weight

1666.16 (free acid)

References & Citations

[1]Cathryn J Kurkjian, et al. The Toll-Like Receptor 2/6 Agonist, FSL-1 Lipopeptide, Therapeutically Mitigates Acute Radiation Syndrome. Sci Rep. 2017 Dec 11;7 (1) :17355.|[2]William A Rose 2nd, et al. FSL-1, a bacterial-derived toll-like receptor 2/6 agonist, enhances resistance to experimental HSV-2 infection. Virol J. 2009 Nov 10;6:195.

Shipping Conditions

Dry Ice

Storage Conditions

-80°C

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

HSV-2; MMP-9; TLR2; TLR6

Citation 01

Adv Sci (Weinh) . 2025 Sep 26:e02395.|Food Res Int. 2022 Dec;162 (Pt A) :112029.|J Ethnopharmacol. 2024 May 10:325:117824.|Int J Med Sci. 2022 Mar 21;19 (4) :631-639.