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PD-334581

PD-334581 is a MEK1 inhibitor[1].

Product Specifications

CAS Number

548756-68-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MEK

Type

Reference compound

Related Pathways

MAPK/ERK Pathway

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd-334581.html

Purity

99.72

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

FC1=C(F)C(NC2=CC=C(C=C2F)I)=C(C3=NN=C(NCCN4CCOCC4)O3)C=C1

Molecular Formula

C20H19F3IN5O2

Molecular Weight

545.30

Precautions

H302, H315, H319, H335

References & Citations

[1]Ohren JF, et al. Structures of human MAP kinase kinase 1 (MEK1) and MEK2 describe novel noncompetitive kinase inhibition. Nat Struct Mol Biol. 2004 Dec;11 (12) :1192-7.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

MEK1

Available Sizes

Frequently Asked Questions

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