Glycylglycine

Glycylglycine is a non-selective glycylglycine dipeptidase substrate and iNOS inhibitor. Glycylglycine can cross the cell membrane by passive diffusion and is hydrolyzed to glycine in the cell, participating in energy metabolism and antioxidant processes. Glycylglycine promotes spermatogonial stem cells (SSCs) proliferation, inhibits astrocyte overactivation and reduces nitric oxide (NO) release, while upregulating the expression of neurotrophic factors (such as PDGFA, FGF2, CNTF) to support nerve myelin repair. Glycylglycine can be used to study male reproductive biology (such as SSCs proliferation regulation) and neurodegenerative diseases (such as neuroprotective mechanisms in multiple sclerosis) [1][2].

Product Specifications

CAS Number

[556-50-3]

Product Name Alternative

Gly-Gly; H-Gly-Gly-OH

UNSPSC

12352209

Hazard Statement

H319

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Diglycine.html

Purity

99.90

Solubility

Acetone : < 1 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(O)CNC(CN)=O

Molecular Formula

C4H8N2O3

Molecular Weight

132.12

Precautions

H319

References & Citations

[1]Xu B, et al. Glycylglycine plays critical roles in the proliferation of spermatogonial stem cells. Mol Med Rep. 2019 Oct;20 (4) :3802-3810.|[2]Zhao C, et al. Metabolomic analysis revealed glycylglycine accumulation in astrocytes after methionine enkephalin administration exhibiting neuron protective effects. J Pharm Biomed Anal. 2015 Nov 10;115:48-54.