Human R-Spondin 1, His-SUMO Tag, HEK293

<strong>Human R-Spondin 1, His-SUMO Tag, HEK293</strong>_x000D_ <strong>Catalog number:</strong> B2018863_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 1 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> ~27 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20¬∞C_x000D_ <strong>Keywords:</strong> Human R-Spondin 1, His-SUMO Tag, HEK293_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Chang CF, Hsu LS, Weng CY, Chen CK, Wang SY, Chou YH, Liu YY, Yuan ZX, Huang WY, Lin H, Chen YH, Tsai JN. N-Glycosylation of Human R-Spondin 1 Is Required for Efficient Secretion and Stability but Not for Its Heparin Binding Ability Int J Mol Sci. 2016 Jun 14;17(6):937._x000D_ 2: Levin G, Koga BAA, Belchior GG, Carreira ACO, Sogayar MC. Production, purification and characterization of recombinant human R-spondin1 (RSPO1) protein stably expressed in human HEK293 cells BMC Biotechnol. 2020 Jan 20;20(1):5._x000D_ 3: Szenker-Ravi E, Altunoglu U, Leushacke M, Bosso-Lef√®vre C, Khatoo M, Thi Tran H, Naert T, Noelanders R, Hajamohideen A, Beneteau C, de Sousa SB, Karaman B, Latypova X, Ba≈üaran S, Y√ºcel EB, Tan TT, Vlaminck L, Nayak SS, Shukla A, Girisha KM, Le Caignec C, Soshnikova N, Uyguner ZO, Vleminckx K, Barker N, Kayserili H, Reversade B. RSPO2 inhibition of RNF43 and ZNRF3 governs limb development independently of LGR4/5/6 Nature. 2018 May;557(7706):564-569._x000D_ 4: Zhang Z, Broderick C, Nishimoto M, Yamaguchi T, Lee SJ, Zhang H, Chen H, Patel M, Ye J, Ponce A, Brady J, Baribault H, Li Y, Yeh WC. Tissue-targeted R-spondin mimetics for liver regeneration Sci Rep. 2020 Aug 18;10(1):13951._x000D_ 5: Peng WC, de Lau W, Madoori PK, Forneris F, Granneman JC, Clevers H, Gros P. Structures of Wnt-antagonist ZNRF3 and its complex with R-spondin 1 and implications for signaling PLoS One. 2013 Dec 12;8(12):e83110._x000D_ 6: Xu Y, Ge K, Lu J, Huang J, Wei W, Huang Q. MicroRNA-493 suppresses hepatocellular carcinoma tumorigenesis through down-regulation of anthrax toxin receptor 1 (ANTXR1) and R-Spondin 2 (RSPO2) Biomed Pharmacother. 2017 Sep;93:334-343._x000D_ 7: Peng WC, de Lau W, Forneris F, Granneman JC, Huch M, Clevers H, Gros P. Structure of stem cell growth factor R-spondin 1 in complex with the ectodomain of its receptor LGR5 Cell Rep. 2013 Jun 27;3(6):1885-92._x000D_ 8: Warner ML, Bell T, Pioszak AA. Engineering high-potency R-spondin adult stem cell growth factors Mol Pharmacol. 2015;87(3):410-20._x000D_ 9: Li C, Cao J, Zhang N, Tu M, Xu F, Wei S, Chen X, Xu Y. Identification of RSPO2 Fusion Mutations and Target Therapy Using a Porcupine Inhibitor Sci Rep. 2018 Sep 24;8(1):14244._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/28739799">10: Carmon KS, Gong X, Yi J, Wu L, Thomas A, Moore CM, Masuho I, Timson DJ, Martemyanov KA, Liu QJ. LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway J Biol Chem. 2017 Sep 8;292(36):14989-15001. </a>_x000D_ _x000D_ <strong>Products Related to Human R-Spondin 1, His-SUMO Tag, HEK293 can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>