Hexaamminecobalt (III) chloride

Hexaamminecobalt (III) chloride is an orally active cobalt coordination compound. Hexaamminecobalt (III) chloride restores the activities of liver antioxidant enzymes (SOD, Catalase) and detoxification enzyme GST. Hexaamminecobalt (III) chloride restores GSH content and reduces DAG. Hexaamminecobalt (III) chloride impairs renal function. Hexaamminecobalt (III) chloride exerts anti-carcinogenic effects in Diethylnitrosamine (HY-N7434) -induced hepatocarcinoma[1][2][3].

Product Specifications

CAS Number

[10534-89-1]

Product Name Alternative

Cobalt hexammine trichloride; Hexaamminecobalt trichloride

UNSPSC

12352200

Hazard Statement

H317, H334, H351, H413

Target

Biochemical Assay Reagents; Glutathione S-transferase; SOD

Type

Biochemical Assay Reagents

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/hexaamminecobalt-iii-chloride.html

Purity

99.50

Solubility

H2O : ≥ 50 mg/mL

Smiles

ClClCl.[Co].N.N.N.N.N.N

Molecular Formula

Cl3CoH18N6

Molecular Weight

267.48

Precautions

H317, H334, H351, H413

References & Citations

[1]Naura AS, et al. Toxic effects of hexaammine cobalt (III) chloride on liver and kidney in mice: Implication of oxidative stress. Drug Chem Toxicol. 2009;32 (3) :293-9. |[2]Naura AS, et al. Anticarcinogenic effects of hexaamminecobalt (III) chloride in mice initiated with diethylnitrosamine. Biol Trace Elem Res. 2007 Nov;119 (2) :147-65. |[3]Naura AS, et al. Studies on mode of action of hexaammine Co (III) chloride against diethylnitrosamine-induced hepatocarcinogenesis in mice. J Biochem Mol Toxicol. 2009 May-Jun;23 (3) :193-201.