Anti-Cytokeratin 19 Antibody

Mouse Monoclonal Antibody specific to Cytokeratin 19

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Cytokeratin-19, CK-19, Keratin-19, K19

Gene Name

KRT19

NCBI Gene ID

UniProt

P08727

Host

Mouse

Reactivity

Human

Immunogen

Recombinant human Cytokeratin 19.

Target Antigen

Keratin, type I cytoskeletal 19

Target

Cytokeratin 19

Clonality

Monoclonal

Isotype

IgG2a

Type

Antibody

Applications

IHC

Field of Research

Cancer research

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Tris

Function

Involved in the organization of myofibers. Together with KRT8, helps to link the contractile apparatus to dystrophin at the costameres of striated muscle. {PubMed:16000376}.

Additionnal Information

<br><br>Immunohistochemistry: use at a dilution of 1:100-1:200 on formalin-fixed, paraffin-embedded samples after heat-induced epitope retrieval at pH 9 for 10-30 minutes.

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

Human Cytokeratin 19. Reactivity with other species has not been investigated.

Formulation

Tris buffer, pH 7.3-7.7, 1% BSA, 0.1% sodium azide.

Buffer pH

pH 7.3-7.7

Target Background

Cytokeratin19 is the smallest member (40kDa) of the keratin family. It forms intermediate filaments in the intracytoplasmic cytoskeleton of epithelial tissue and provides mechanical support. Cytokeratin 19 is identified in epithelial malignancies such as carcinomas of colon, stomach, pancreas, biliary tract, liver, breast, and thyroid papillary carcinomas.