Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

Catalytic activity: Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin. Disease: Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM: 612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect. function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. similarity: Belongs to the peptidase S1 family. similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. similarity: Contains 1 peptidase S1 domain. similarity: Contains 4 apple domains. subunit: The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.