P-gp inhibitor 20
P-gp inhibitor 20 (compound H27) is a low cytotoxicity P-glycoprotein (P-gp) inhibitor. P-gp inhibitor 20 inhibits the efflux function of P-gp in a dose-dependent manner (without affecting the expression of P-gp), thereby reversing the multidrug resistance (MDR) of MCF-7/ADR cells, with an IC50 value of 46.6 nM. P-gp inhibitor 20 can be used for cancer research[1].
Product Specifications
UNSPSC
12352005
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-inhibitor-20.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC([Se]C2=CNC3=CC=C(C4=CN(C)N=C4)C=C32)=C1)N5CCC6=CC(OC)=C(OC)C=C6C5
Molecular Formula
C30H28N4O3Se
Molecular Weight
571.53
References & Citations
[1]Yang Z, et al. Design, synthesis, and bioactivity evaluation of novel indole-selenide derivatives as P-glycoprotein inhibitors against multi-drug resistance in MCF-7/ADR cell. Eur J Med Chem. 2024 Feb 10;268:116207.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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