IRF3 (S386A, S396A mutant)

<strong>IRF3 (S386A, S396A mutant)</strong>_x000D_ <strong>Catalog number:</strong> B2018777_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 49.3 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> IRF3 Negative Control_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Al Hamrashdi M, Brady G. Regulation of IRF3 activation in human antiviral signaling pathways Biochem Pharmacol. 2022 Jun;200:115026._x000D_ 2: Tian M, Wang X, Sun J, Lin W, Chen L, Liu S, Wu X, Shi L, Xu P, Cai X, Wang X. IRF3 prevents colorectal tumorigenesis via inhibiting the nuclear translocation of β-catenin Nat Commun. 2020 Nov 13;11(1):5762._x000D_ 3: Yan S, Kumari M, Xiao H, Jacobs C, Kochumon S, Jedrychowski M, Chouchani E, Ahmad R, Rosen ED. IRF3 reduces adipose thermogenesis via ISG15-mediated reprogramming of glycolysis J Clin Invest. 2021 Apr 1;131(7):e144888._x000D_ 4: Dai T, Zhang L, Ran Y, Zhang M, Yang B, Lu H, Lin S, Zhang L, Zhou F. MAVS deSUMOylation by SENP1 inhibits its aggregation and antagonizes IRF3 activation Nat Struct Mol Biol. 2023 Jun;30(6):785-799._x000D_ 5: King KR, Aguirre AD, Ye YX, Sun Y, Roh JD, Ng RP Jr, Kohler RH, Arlauckas SP, Iwamoto Y, Savol A, Sadreyev RI, Kelly M, Fitzgibbons TP, Fitzgerald KA, Mitchison T, Libby P, Nahrendorf M, Weissleder R. IRF3 and type I interferons fuel a fatal response to myocardial infarction Nat Med. 2017 Dec;23(12):1481-1487._x000D_ 6: Tanaka Y, Chen ZJ. STING specifies IRF3 phosphorylation by TBK1 in the cytosolic DNA signaling pathway Sci Signal. 2012 Mar 6;5(214):ra20._x000D_ 7: Liu H, Ye G, Liu X, Xue M, Zhou Q, Zhang L, Zhang K, Huang L, Weng C. Vimentin inhibits type I interferon production by disrupting the TBK1-IKKε-IRF3 axis Cell Rep. 2022 Oct 11;41(2):111469._x000D_ 8: Zhong B, Yang Y, Li S, Wang YY, Li Y, Diao F, Lei C, He X, Zhang L, Tien P, Shu HB. The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation Immunity. 2008 Oct 17;29(4):538-50._x000D_ 9: Zhuang Y, Ortega-Ribera M, Thevkar Nagesh P, Joshi R, Huang H, Wang Y, Zivny A, Mehta J, Parikh SM, Szabo G. Bile acid-induced IRF3 phosphorylation mediates cell death, inflammatory responses, and fibrosis in cholestasis-induced liver and kidney injury via regulation of ZBP1 Hepatology. 2024 Apr 1;79(4):752-767._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/37792941">10: Ren Y, Wang A, Zhang B, Ji W, Zhu XX, Lou J, Huang M, Qiu Y, Zhou X. Human cytomegalovirus UL36 inhibits IRF3-dependent immune signaling to counterbalance its immunoenhancement as apoptotic inhibitor Sci Adv. 2023 Oct 6;9(40):eadi6586. </a>_x000D_ _x000D_ <strong>Products Related to IRF3 (S386A, S396A mutant) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>