Bruceantinol

Bruceantinol is a quassinoid that can be isolated from Brucea javanica, inhibits pepper mottle virus (PepMoV) in pepper. Bruceantinol is a STAT3 inhibitor demonstrating potent antitumor activity in in vitro and in vivo human colorectal cancer (CRC) models. Bruceantinol has potent anti-leukemic activity. Bruceantinol strongly inhibits STAT3 DNA-binding ability (IC50 = 2.4 pM), blocks the constitutive and IL-6-induced STAT3 activation, and suppresses transcription of MCL-1, PTTG1, survivin and c-Myc. Bruceantinol binds with CDK2/4/6 to facilitate protein degradation through proteasome pathway. Bruceantinol can dose- and time-dependently reduces the cell growth, impede cell proliferation, disrupts the cell cycle, and induces necrosis in MCF-7 cells and apoptosis in MDA-MB-231 cells[1][2][3].

Product Specifications

CAS Number

[53729-52-5]

UNSPSC

12352005

Hazard Statement

H315, H319

Target

Apoptosis; Bcl-2 Family; CDK; c-Myc; Necroptosis; Ser/Thr Kinase; STAT; Survivin

Type

Natural Products

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; JAK/STAT Signaling; Metabolic Enzyme/Protease; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bruceantinol.html

Purity

98.89

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

COC([C@]12[C@@]3([H])[C@@]4(CO2)[C@@]([C@H]([C@@H]1O)O)([H])[C@@]5([C@@](C(C)=C(C(C5)=O)O)([H])C[C@@]4([H])OC([C@@H]3OC(/C=C(C)/C(C)(C)OC(C)=O)=O)=O)C)=O

Molecular Formula

C30H38O13

Molecular Weight

606.61

Precautions

H315, H319

References & Citations

[1]Seung Mok Ryu, et al. Quassinoids isolated from Brucea javanica inhibit pepper mottle virus in pepper. Virus Res. 2017 Jan 2;227:49-56.|[2]Ning Wei, et al. Targeting colon cancer with the novel STAT3 inhibitor bruceantinol. Oncogene. 2019 Mar;38 (10) :1676-1687.|[3]Sun, L., et al., (2024) . Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells. Chemico-biological interactions, 395, 110999.