Fosmidomycin
Fosmidomycin is an orally active antibiotic, which exhibits antimalarial activity through inhibition of 1-deoxy-D-xylulose 5-phosphate reductoisomerase (DOXP reductoisomerase) . Fosmidomycin inhibits P. falciparum strains 3D7, HB3, Dd2 and A2, with IC50s of 150, 71, 170 and 150 ng/mL, respectively. Fosmidomycin exhibits synergistic effect with Clindamycin (HY-B1455), and ameliorates malaria in mouse model[1].
Product Specifications
CAS Number
[66508-53-0]
UNSPSC
12352211
Target
Antibiotic; Parasite
Type
Natural Products
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/fosmidomycin.html
Smiles
OP(O)(CCCN(C=O)O)=O
Molecular Formula
C4H10NO5P
Molecular Weight
183.10
References & Citations
[1]Wiesner J, et al., In vitro and in vivo synergy of fosmidomycin, a novel antimalarial drug, with clindamycin. Antimicrob Agents Chemother. 2002 Sep;46 (9) :2889-94.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
Phase 3
Curated Selection
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