(2R,4R) -APDC

(2R,4R) -APDC is a group II metabotropic glutamate receptor (mGluR) agonist. (2R,4R) -APDC affects cell proliferation by inhibiting glutamate release, enhancing motor responses produced by D1 receptor activation, or reducing brain-derived neurotrophic factor (BDNF) levels. (2R,4R) -APDC can be used in the study of epilepsy and other neurological diseases[1][2].

Product Specifications

CAS Number

[169209-63-6]

Product Name Alternative

(2R,4R) -4-Aminopyrrolidine-2,4-dicarboxylic acid

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2r-4r-apdc.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H]1NC[C@](C(O)=O)(N)C1)O

Molecular Formula

C6H10N2O4

Molecular Weight

174.15

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Folbergrová J, et al. Posttreatment with group II metabotropic glutamate receptor agonist 2R,4R-4-aminopyrrolidine-2,4-dicarboxylate is only weakly effective on seizures in immature rats. Brain Res. 2009 Jun 1;1273:144-54.|[2]Yao H, et al. 2R, 4R-APDC decreases cell proliferation in the dentate gyrus of adult rats: the effect of 2R, 4R-APDC on cell proliferation. Neuroreport. 2007 Sep 17;18 (14) :1459-62.