BMX-001

BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. BMX-001 reduces apoptosis in human and murine islets. BMX-001 significantly improves static-glucose stimulated insulin secretion (sGSIS) responses in murine islets. BMX-001 can significantly restore euglycemia in murine islet studies in the presence of the MnSOD. BMX-001 reduces the generation of ROS in a murine islet isolation and culture model[1].

Product Specifications

CAS Number

[1379783-91-1]

UNSPSC

12352005

Target

Apoptosis; Reactive Oxygen Species (ROS)

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bmx-001.html

Smiles

CCCCOCC[N+]1=C(C=CC=C1)C2=C3C=CC4=C(C5=[N+](CCOCCCC)C=CC=C5)C6=[N]7[Mn+3]8([N-]34)[N-]9C(C(C%10=[N+](C=CC=C%10)CCOCCCC)=C%11C=CC2=[N]8%11)=CC=C9C(C%12=[N+](CCOCCCC)C=CC=C%12)=C7C=C6.[Cl-].[Cl-].[Cl-].[Cl-].[Cl-]

Molecular Formula

C64H76Cl5MnN8O4

Molecular Weight

1253.54

References & Citations

[1]Antonio Bruni, et al. BMX-001, a novel redox-active metalloporphyrin, improves islet function and engraftment in a murine transplant model. Am J Transplant. 2018 Aug;18 (8) :1879-1889.