Benzocaine
Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.
Product Specifications
CAS Number
94-09-7
UNSPSC
12352005
Hazard Statement
H317, H402
Target
Bacterial; Sodium Channel
Type
Reference compound
Related Pathways
Anti-infection; Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/Benzocaine.html
Purity
99.98
Solubility
DMSO : ≥ 100 mg/mL|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(OCC)C1=CC=C(N)C=C1
Molecular Formula
C9H11NO2
Molecular Weight
165.19
Precautions
H317, H402
References & Citations
[1]Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435 (2) :293-302.|[2]Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388 (11) :1163-70.|[3]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54 (8) :1322-6.
Shipping Conditions
Room Temperature
Storage Conditions
RT, protect from light
Scientific Category
Reference compound1
Clinical Information
Launched
Available Sizes
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