Benzocaine

Benzocaine shares a common receptor with all othe rLAs in the voltage-gated Na+ channel, with an IC50 of 0.8 mM tested with a potential of +30 mV.

Product Specifications

CAS Number

[94-09-7]

UNSPSC

12352005

Hazard Statement

H317, H402

Target

Bacterial; Sodium Channel

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Benzocaine.html

Purity

99.98

Solubility

DMSO : ≥ 100 mg/mL|H2O : 2 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OCC)C1=CC=C(N)C=C1

Molecular Formula

C9H11NO2

Molecular Weight

165.19

Precautions

H317, H402

References & Citations

[1]Wang GK et al. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998 Jan;435 (2) :293-302.|[2]Di Croce D et al. Drug action of benzocaine on the sarcoplasmic reticulum Ca-ATPase from fast-twitch skeletal muscle. Naunyn Schmiedebergs Arch Pharmacol. 2015 Nov;388 (11) :1163-70.|[3]Davis JA, et al. Benzocaine-induced methemoglobinemia attributed to topical application of the anesthetic in several laboratory animal species. Am J Vet Res. 1993 Aug;54 (8) :1322-6.