Mps1-IN-10

Mps1-IN-10 (Compound 9) is an inhibitor for Mps1 with an IC50 of 6.4 nM. Mps1-IN-10 inhibits the proliferation of cancer cell MDA-MB-231 with a GI50 of 11 nM. Mps1-IN-10 exhibits anti-tumor efficacy in mice MDA-MB-231 xenograft models[1].

Product Specifications

CAS Number

[2489220-49-5]

UNSPSC

12352005

Target

Mps1

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/mps1-in-10.html

Purity

98.20

Smiles

N#CC1=CNC2=NC(NC3=CC=C(N4C(CCC4)=O)C=C3OC)=NC(NC5CCCCC5)=C21

Molecular Formula

C24H27N7O2

Molecular Weight

445.52

References & Citations

[1]Lee Y, et al., X-ray Crystal Structure-Guided Design and Optimization of 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J Med Chem. 2021 May 27;64 (10) :6985-6995.