α5β1 integrin agonist-1

α5β1 integrin agonist-1 is an α5β1 integrin agonist, with an EC50 of 1.5 nM. α5β1 integrin agonist-1 inhabits α4β1 integrin (IC50 = 2.99 μM) in Jurkat/VCAM-1 adhesion assayα5β1 integrin agonist-1 induces concentration-dependent apoptosis and activates the caspase 3/7 pathway in α5β1 integrin-expressing K562 cancer cells. α5β1 integrin agonist-1 can be used for the study of cancer[1].

Product Specifications

CAS Number

[2756557-83-0]

UNSPSC

12352005

Target

Apoptosis; Caspase; Integrin

Type

Reference compound

Related Pathways

Apoptosis; Cytoskeleton

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/α5β1-integrin-agonist-1.html

Purity

99.67

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

OC(C[C@H]1N(C([C@]1([H])[C@@H](C)OC(CCNC(CN2C(NC(C(F)=C2)=O)=O)=O)=O)=O)C(NC3=C(C=CC=C3)C)=O)=O

Molecular Formula

C24H26FN5O9

Molecular Weight

547.49

References & Citations

[1]Baiula M, et al. Selective Integrin Ligands Promote Cell Internalization of the Antineoplastic Agent Fluorouracil. ACS Pharmacol Transl Sci. 2021 Sep 2;4 (5) :1528-1542.