Oleanonic acid

Oleanonic acid (3-Oxooleanolic acid) is an orally available triterpene that has anti-inflammatory and insecticidal properties. In vitro, oleanonic acid can improve oxidative stress, autophagy defects, ferroptosis, mitochondrial damage, and endoplasmic reticulum stress induced by Amyloid-β, and in vivo, it can alleviate myocardial hypertrophy in rats[1][2][3][4][5].

Product Specifications

CAS Number

[17990-42-0]

Product Name Alternative

3-Oxooleanolic acid

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Amyloid-β; Autophagy; Ferroptosis; HIV

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/Oleanonic-acid.html

Purity

99.63

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

CC1(C)C(CC[C@]2(C)[C@@]3([H])CC=C4[C@]5([H])CC(C)(C)CC[C@@](C(O)=O)5CC[C@](C)4[C@@](C)3CC[C@@]12[H])=O

Molecular Formula

C30H46O3

Molecular Weight

454.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Giner-Larza EM et al.Oleanonic acid, a 3-oxotriterpene from Pistacia, inhibits leukotriene synthesis and has anti-inflammatory activity.Eur J Pharmacol.Sep 28;428 (1) :137-43.doi:10.1016/S0014-2999 (01) 01290-0 (2001) |[2]Fabio Mengoni.Anti-HIV Activity of Oleanolic Acid on Infected Human Mononuclear Cells.Planta Med 68 (2) : 111-114.DOI: 10.1055/s-2002-20256 (2002) |[3]Cristiano S. FUNARI, et al. Oleanonic acid from Lippia lupulina (Verbenaceae) .shows strong in vitro antileishmanial and antitrypanosomal activity. Acta Amazonica. 46 (4) .Oct-Dec 2016 |[4]Hui Gao, et al. Oleanonic acid ameliorates pressure overload-induced cardiac hypertrophy in rats: The role of PKCζ-NF-κB pathway. Mol Cell Endocrinol. 2018 Jul 15:470:259-268.|[5]Liqing Tao, et al. Oleanonic acid ameliorates mutant Aβ precursor protein-induced oxidative stress, autophagy deficits, ferroptosis, mitochondrial damage, and ER stress in vitro. Biochim Biophys Acta Mol Basis Dis. 2024 Dec;1870 (8) :167459.