ZBT7A Polyclonal Antibody

Function:Plays a key role in the instruction of early lymphoid progenitors to develop into B lineage by repressing T-cell instructive Notch signals (By similarity) . Specifically represses the transcription of the CDKN2A gene. Efficiently abrogates E2F1-dependent CDKN2A transactivation/de-repression. Binds to the consensus sequence 5'-[GA][CA]GACCCCCCCCC-3'., similarity:Contains 1 BTB (POZ) domain., similarity:Contains 4 C2H2-type zinc fingers., subunit:Interacts with BCL6., tissue specificity:Widely expressed. In normal thymus, expressed in medullary epithelial cells and Hassle's corpuscles (at protein level) . In tonsil, expressed in squamous epithelium and germinal center lymphocytes (at protein level) . Up-regulated in a subset of lymphomas, as well as in a subset of breast, lung, colon, prostate and bladder carcinomas (at protein level) .