PAC-1

PAC-1 is a procaspase-3 activator that induces apoptosis in cancer cells with an EC50 of 2.08 μM.

Product Specifications

CAS Number

[315183-21-2]

Product Name Alternative

Procaspase activating compound 1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335, H400

Target

Apoptosis; Autophagy; Caspase

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PAC-1.html

Purity

99.88

Solubility

DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL

Smiles

O=C(N/N=C/C1=CC=CC(CC=C)=C1O)CN2CCN(CC3=CC=CC=C3)CC2

Molecular Formula

C23H28N4O2

Molecular Weight

392.49

Precautions

H302, H315, H319, H335, H400

References & Citations

[1]Wang F, et al. A novel small-molecule activator of procaspase-3 induces apoptosis in cancer cells and reduces tumor growth in human breast, liver and gallbladder cancer xenografts. Mol Oncol. 2014 Dec;8 (8) :1640-52.|[2]Seervi M, et al. ERO1α-dependent endoplasmic reticulum-mitochondrial calcium flux contributes to ER stress and mitochondrial permeabilization by procaspase-activating compound-1 (PAC-1) . Cell Death Dis. 2013 Dec 19;4:e968.|[3]Putt KS, et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol. 2006 Oct;2 (10) :543-50.