STAT5a Polyclonal Antibody
Product Specifications
Background
Signal transducer and activator of transcription 5A (STAT5A) Homo sapiens The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X (L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been
Product Name Alternative
Signal transducer and activator of transcription 5A; YM3467
Gene ID
6776
Swiss Prot
P42229
Cross Reactivity
Rat; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF (paraffin section)
Dilution
Western Blot: 1/500 - 1/2000.IHC-p/f:1:50-300. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
90
Storage Conditions
-20°C/1 year
Protein Weight
90
Available Sizes
Curated Selection
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