S28A1 Polyclonal Antibody

Function:Sodium-dependent and pyrimidine-selective. Exhibits the transport characteristics of the nucleoside transport system cit or N2 subtype (N2/cit) (selective for pyrimidine nucleosides and adenosine) . It also transports the antiviral pyrimidine nucleoside analogs 3'-azido-3'-deoxythymidine (AZT) and 2',3'-dideoxycytidine (ddC) . It may be involved in the intestinal absorption and renal handling of pyrimidine nucleoside analogs used to treat acquired immunodeficiency syndrome (AIDS) . It has the following selective inhibition: adenosine, thymidine, cytidine, uridine >> guanosine, inosine., polymorphism:Three variant forms of isoform 1 (A, B and C) are expressed in the kidney. All three variant forms have similar nucleoside transport activity., similarity:Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family., tissue specificity:Expressed in kidney.