PKN3 Polyclonal Antibody

Catalytic activity:ATP + a protein = ADP + a phosphoprotein., domain:The C1 domain does not bind the diacylglycerol (DAG) ., enzyme regulation:Two specific sites, Thr-718 (activation loop of the kinase domain) and Thr-860 (turn motif), need to be phosphorylated for its full activation., function:Contributes to invasiveness in malignant prostate cancer., PTM:Autophosphorylated., similarity:Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily., similarity:Contains 1 AGC-kinase C-terminal domain., similarity:Contains 1 protein kinase domain., similarity:Contains 3 REM (Hr1) repeats., subcellular location:Nuclear and perinuclear Golgi region., tissue specificity:Expressed in prostate tumors and various cancer cell lines. Not expressed in adult tissues.