PARP9 Polyclonal Antibody

Catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., miscellaneous:Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration., similarity:Contains 1 PARP catalytic domain., similarity:Contains 2 Macro domains., subunit:Interacts with BBAP., tissue specificity:Expressed in lymphocyte-rich tissues, spleen, lymph nodes, peripheral blood lymphocytes and colonic mucosa. Also expressed in nonhematopoietic tissues such as heart and skeletal muscle. Isoform 2 is the predominant form.