NEDD4L rabbit pAb
Product Specifications
Background
This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates, thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel, ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Mar 2012]
Product Name Alternative
E3 ubiquitin-protein ligase NEDD4-like (EC 6.3.2.-) (NEDD4.2) (Nedd4-2)
Gene ID
23327
Swiss Prot
Q96PU5
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB
Dilution
WB 1:500-2000
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.08% sodium azide.
Molecular Weight
110-120
Storage Conditions
-20°C/1 year
Protein Weight
110-120
Available Sizes
Curated Selection
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