KDM3B Polyclonal Antibody

Cofactor:Binds 1 Fe (2+) ion per subunit., domain:Leu-Xaa-Xaa-Leu-Leu (LXXLL) motifs are known to mediate the association with nuclear receptors., function:Histone demethylase that specifically demethylates 'Lys-9' of histone H3, thereby playing a central role in histone code. Demethylation of Lys residue generates formaldehyde and succinate. May have tumor suppressor activity., miscellaneous:Its gene is located in the 5q region of the genome which is deleted in del (5q) interstitial deletion, a frequent deletion found in myeloid leukemias and myelodysplasias, suggesting that it may be a good candidate for the del (5q) tumor suppressor gene., similarity:Belongs to the JHDM2 histone demethylase family., similarity:Contains 1 JmjC domain., tissue specificity:Ubiquitous. Highly expressed in placenta, skeletal muscle, kidney, heart and liver.