HECW1 Polyclonal Antibody
Product Specifications
Background
Function:E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent degradation of DVL1. Also targets the mutant SOD1 protein involved in familial amyotrophic lateral sclerosis (FALS) . Forms cytotoxic aggregates with DVL1, SSR3 and mutant SOD1 that lead to motor neuron death in FALS., pathway:Protein modification; protein ubiquitination., similarity:Contains 1 C2 domain., similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain., similarity:Contains 2 WW domains., subunit:Interacts with DVL1 and SSR3. Also interacts with mutant SOD1., tissue specificity:Predominantly expressed in neurons of adult and fetal brain. Weakly expressed in the kidney.
Gene ID
23072
Swiss Prot
Q76N89
Cross Reactivity
Human; Rat; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Buffer
Liquid in PBS containing 50% glycerol, and 0.02% sodium azide.
Molecular Weight
176
Storage Conditions
-20°C/1 year
Protein Weight
176
Available Sizes
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