Pelubiprofen

Pelubiprofen is an orally active anti-inflammatory agent that inhibits COX enzyme activity (with IC50 values of 10.66 and 2.88 μM for COX-1 and COX-2, respectively) . Pelubiprofen has significant anti-inflammatory and analgesic effects[1][2].

Product Specifications

CAS Number

[69956-77-0]

UNSPSC

12352005

Target

COX; IKK; MAP3K; NF-κB; NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation; MAPK/ERK Pathway; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/pelubiprofen.html

Purity

99.27

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(O)C(C)C1=CC=C(/C=C2C(CCCC/2)=O)C=C1

Molecular Formula

C16H18O3

Molecular Weight

258.31

References & Citations

[1]Choi IA, Baek HJ, et al. Comparison of the efficacy and safety profiles of a pelubiprofen versus celecoxib in patients with rheumatoid arthritis: a 6-week, multicenter, randomized, double-blind, phase III, non-inferiority clinical trial. BMC Musculoskelet Disord. 2014 Nov 18;15:375.|[2]Ji-Sun Shin, et al. Anti-inflammatory effect of pelubiprofen, 2-[4- (oxocyclohexylidenemethyl) -phenyl]propionic acid, mediated by dual suppression of COX activity and LPS-induced inflammatory gene expression via NF-κB inactivation. J Cell Biochem. 2011 Dec;112 (12) :3594-603.