HG-9-91-01
HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.
Product Specifications
CAS Number
1456858-58-4
Product Name Alternative
SIK inhibitor 1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Salt-inducible Kinase (SIK)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/HG-9-91-01.html
Concentration
10mM
Purity
99.77
Solubility
DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
CC1=CC=CC(C)=C1NC(N(C2=NC=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=C2)C5=CC=C(OC)C=C5OC)=O
Molecular Formula
C32H37N7O3
Molecular Weight
567.68
Precautions
H302, H315, H319, H335
References & Citations
[1]Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated andregulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109 (42) :16986-91.|[2]Sundberg TB, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111 (34) :12468-73.|[3]Patel K, et al.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun. 2014 Aug 4;5:4535.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
SIK1; SIK2; SIK3
Available Sizes
Frequently Asked Questions
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