HG-9-91-01

HG-9-91-01 is a potent and highly selective salt-inducible kinase (SIK) inhibitor with IC50s of 0.92 nM, 6.6 nM and 9.6 nM for SIK1, SIK2 and SIK3 respectively.

Product Specifications

CAS Number

[1456858-58-4]

Product Name Alternative

SIK inhibitor 1

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Salt-inducible Kinase (SIK)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/HG-9-91-01.html

Concentration

10mM

Purity

99.77

Solubility

DMSO : 250 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

CC1=CC=CC(C)=C1NC(N(C2=NC=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=C2)C5=CC=C(OC)C=C5OC)=O

Molecular Formula

C32H37N7O3

Molecular Weight

567.68

Precautions

H302, H315, H319, H335

References & Citations

[1]Clark K, et al. Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated andregulatory macrophages. Proc Natl Acad Sci U S A. 2012 Oct 16;109 (42) :16986-91.|[2]Sundberg TB, et al. Small-molecule screening identifies inhibition of salt-inducible kinases as a therapeutic strategy to enhance immunoregulatory functions of dendritic cells. Proc Natl Acad Sci U S A. 2014 Aug 26;111 (34) :12468-73.|[3]Patel K, et al.The LKB1-salt-inducible kinase pathway functions as a key gluconeogenic suppressor in the liver. Nat Commun. 2014 Aug 4;5:4535.