BEX3 Polyclonal Antibody

Domain:The nuclear export signal is required for export from the nucleus and the interactions with itself and p75NTR/NGFR., function:May be a signaling adapter molecule involved in p75NTR-mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death (By similarity) . May play an important role in the pathogenesis of neurogenetic diseases., miscellaneous:Binds transition metals., PTM:Ubiquitinated. Degraded by the proteasome., similarity:Belongs to the BEX family., subcellular location:Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria., subunit:Self-associates. Interacts with 14-3-3 epsilon (YWHAE) . Interacts with DIABLO/SMAC (By similarity) . Binds to the DEATH domain of p75NTR/NGFR., tissue specificity:Found in ovarian granulosa cells, testis, prostate and seminal vesicle tissue. High levels also detected in liver.