TOP2A (Phospho Ser1213) rabbit pAb

Catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA., enzyme regulation:Specifically inhibited by the intercalating agent amsacrine., function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks., miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils., PTM:Phosphorylation has no effect on catalytic activity., similarity:Belongs to the type II topoisomerase family., subcellular location:Generally located in the nucleoplasm., subunit:Homodimer. Interacts with COPS5.