Neddylin Polyclonal Antibody
Product Specifications
Background
Function:Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins., PTM:Cleavage of precursor form by UCHL3 or SENP8 is necessary for function., similarity:Belongs to the ubiquitin family., subcellular location:Mainly nuclear., subunit:Directly interacts with NUB1 and AHR. Covalently attached to cullins and p53., tissue specificity:Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.
Product Name Alternative
NEDD8; NEDD8; Neddylin; Neural precursor cell expressed developmentally down-regulated protein 8; NEDD-8; Ubiquitin-like protein Nedd8
Gene ID
4738
Swiss Prot
Q15843
Cross Reactivity
Human; Mouse; Rat; Monkey
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF (paraffin section) ; ELISA
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
85
Storage Conditions
-20°C/1 year
Protein Weight
85
Available Sizes
Curated Selection
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