MYPT1/2 (Phospho Ser668/Ser618) rabbit pAb

Function:Regulates myosin phosphatase activity., PTM:Phosphorylated by CIT (Rho-associated kinase) (By similarity) . Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Contains 6 ANK repeats., subcellular location:Along actomyosin filaments and stress fibers., subunit:PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12A mediates binding to myosin. Interacts with ARHA and CIT (By similarity) . Binds PPP1R12B, ROCK1 and IL16.

Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1; Myosin phosphatase target subunit 1; Protein phosphatase myosin-binding subunit)