AG 99

AG 99 (Tyrphostin 46), a tyrphostin derivative, is a tyrosine kinase inhibitor that increases sister chromatid exchange frequency in transformed CHO-K1 and primary CHE cells. AG 99 is promising for research of proliferative diseases[1].

Product Specifications

CAS Number

[118409-59-9]

Product Name Alternative

Tyrphostin 46; Tyrphostin AG 99

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Tyrosinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/ag-99.html

Smiles

O=C(/C(C#N)=C/C1=CC=C(C(O)=C1)O)N

Molecular Formula

C10H8N2O3

Molecular Weight

204.18

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bassi L, et al. Clastogenic effects of two tyrosine kinase inhibitors, tyrphostin 23 and tyrphostin 46, on a transformed (CHO-K1) and on a primary embryonic chinese hamster cell line (CHE) . Mutagenesis. 2000 Jul;15 (4) :341-7.|[2]Hubert EM, et al. Inhibition of volume-stimulated taurine efflux and tyrosine kinase activity in the skate red blood cell. Pflugers Arch. 2000 May;440 (1) :132-9.