LRRC41 Polyclonal Antibody

Caution:It is uncertain whether Met-1 or Met-23 is the initiator., domain:The elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x (3) -C-x (3) -[AILV]., function:Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins., pathway:Protein modification; protein ubiquitination., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Translation N-terminally extended., similarity:Contains 7 LRR (leucine-rich) repeats., subunit:Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS (LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.