Ksr2 Polyclonal Antibody
Product Specifications
Background
Domain:The protein kinase domain is predicted to be catalytically inactive., function:Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production., PTM:Phosphorylated on Ser-474 by MARK3., similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family., similarity:Contains 1 phorbol-ester/DAG-type zinc finger., similarity:Contains 1 protein kinase domain., subunit:Interacts with MAP2K1, MAP3K8, MAPK, RAS and RAF., tissue specificity:Mainly expressed in brain and kidney.
Product Name Alternative
KSR2; Kinase suppressor of Ras 2; hKSR2
Gene ID
283455
Swiss Prot
Q6VAB6
Cross Reactivity
Human; Mouse
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF/ICC; ELISA
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
108
Storage Conditions
-20°C/1 year
Protein Weight
108
Available Sizes
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