DG-041
Product Specifications
UNSPSC Description
DG-041 is a potent, high affinity and selective EP3 receptor antagonist with IC50s of 4.6 nM and 8.1 nM in the binding and FLIPR assay, respectively. DG-041 inhibits PGE2 facilitation of platelet aggregation. DG-041 crosses the blood-brain barrier[1][2].
Target Antigen
Prostaglandin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/dg-041.html
Purity
99.0
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
O=C(NS(=O)(C1=CC(Cl)=C(Cl)S1)=O)/C=C/C2=CC(F)=CC3=C2N(CC4=CC=C(Cl)C=C4Cl)C=C3C
Molecular Weight
592.32
References & Citations
[1]Singh J, et al. Antagonists of the EP3 receptor for prostaglandin E2 are novel antiplatelet agents that do not prolong bleeding. ACS Chem Biol. 2009 Feb 20;4(2):115-26.|[2]Hategan G, et al. Heterocyclic 1,7-disubstituted indole sulfonamides are potent and selective human EP3 receptorantagonists. Bioorg Med Chem Lett. 2009 Dec 1;19(23):6797-800.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-10835/DG-041-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-10835/DG-041-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
861238-35-9
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS6469945-01 0.2 mL
COMP, ID (Cartilage Oligomeric Matrix Protein, Thrombospondin-5, TSP5) (Azide free) (HRP)
Ask
View Details MBS6469945-02 5x 0.2 mL
COMP, ID (Cartilage Oligomeric Matrix Protein, Thrombospondin-5, TSP5) (Azide free) (HRP)
Ask
View Details MBS7220727-01 48 Well
Human Coiled coil domain containing protein 91 (CCDC91) ELISA Kit
Ask
View Details