Csk Polyclonal Antibody
Product Specifications
Background
Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., function:Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases., PTM:Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily., similarity:Contains 1 protein kinase domain., similarity:Contains 1 SH2 domain., similarity:Contains 1 SH3 domain., subcellular location:Mainly cytoplasmic, also present in lipid rafts., subunit:Interacts with PTPN8 (By similarity) . Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1., tissue specificity:Expressed in lung and macrophages.
Product Name Alternative
CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL
Gene ID
1445
Swiss Prot
P41240
Cross Reactivity
Human; Mouse; Rat
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IF/ICC; ELISA
Dilution
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
55
Storage Conditions
-20°C/1 year
Protein Weight
55
Available Sizes
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