Crk II Polyclonal Antibody
Product Specifications
Background
CRK proto-oncogene, adaptor protein (CRK) Homo sapiens This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
Product Name Alternative
CRK; Adapter molecule crk; Proto-oncogene c-Crk; p38
Gene ID
1398
Swiss Prot
P46108
Cross Reactivity
Human; Mouse; Rat; Monkey
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC-p; IF/ICC; ELISA
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Molecular Weight
40
Storage Conditions
-20°C/1 year
Protein Weight
40
Available Sizes
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